Small interfering microRNA molecules (miRNAs) are non-coding RNA regulatory molecules that control a wide array of biological processes by translational inhibition. Due to their ability to be released into the blood as well as their sufficient stability in body fluids, miRNAs are used as specific biomarkers of numerous physiological and pathophysiological cellular processes.
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Acute myocardial infarctions (AMI) and coronary artery disease (CAD) are major causes of mortality and morbidity worldwide. About 10% of patients who are admitted to emergency departments with chest pain every year are diagnosed with heart attack. AMI is a condition that can be due to ischemic heart disease or coronary artery disease in conjunction, and it becomes manifest when an atherosclerotic plate rupture and a developing thrombus occludes the coronary artery totally or partially, restricting blood access to the heart.
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